Restyl(R) (Alprazolam) is an anxiloytic, a triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions.
It is highly efficacious for the treatment of Generalized Anxiety Disorder, depression, stress disorders, Traumatic Stress Disorder, Panic Disorder, with or with out Agoraphobia. It also has an analgesic effect on chronic and organic pain of malignant origin.
Why do we need to take Restyl (Alprazolam)?
Restyl is very effective in the treatment of Generalized Anxiety in particular. In our day-to-day stress filled lives anxiety seems to be our constant companion. In order to raise the quality of life and relieve us from stress Restyl is a good medication to start with under medical supervision. Restyl also helps patients with panic disorders, depression and so on to lead a comparatively normal and anxiety free life. As we are all aware anxiety can lead to many serious complications especially cardiac problems.
How Does Restyl act?
Their exact mechanism of action is unknown. Clinically, all benzodiazepines cause a dose-related central nervous system depressant activity varying from mild impairment of task performance to hypnosis. Alprazolam binds to the GABAA, subtype of the GABA receptor, increasing inhibitory effects of GABA within the central nervous system. The binding site for benzodiazepines is distinct from the binding site for GABA on the GABA receptor.
There are certain things, which you should know before taking Restyl (Alprazolam)
Alprazolam concentrations may be reduced by up to 50% in smokers compared to non-smokers
If Alprazolam is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus and ideally discontinue the drug.
Alcohol should not be generally consumed during the treatment with Alprazolam
Alprazolam undergoes transplacental passage and is excreted in human milk, nursing mothers should follow physician’s assistance in this case
Drugs that you need to be careful while taking Restyl
Avoid Potent CYP3A inhibitors –Increases the drug concentration of Alprazolam for e.g Ketoconazole, Itraconazol, other Azole-type antifungal agents, Nefazodone, Fluvoxamine, Cimetidine, Fluoxetine, Propoxyphene, Oral Contraceptives – In this case dose needs to be reduced to avoid adverse effects
Potent CYP3A inducers—Carbamazepine may decrease Alprazolam -- in this case dose should be increased in order to achieve desired therapeutic effect
Possible drug interactions have been reported with Diltiazem, Isoniazid, Macrolide antibiotics such as Erythromycin and Clarithromycin, and Grapefruit juice
Common problems that you may encounter with treatment of Restyl
Drug withdrawal syndrome is the most common of all
Psychological Dependence
Inter Dose Anxiety
Common side effects that may be encountered with the treatment of Restyl
Sedation
Somnolence
Dysarthria
Abnormal coordination
In geriatric patients the
Dose needs to be properly adjusted and administered as metabolic activities are low in geriatric patients and they suffer from co morbid conditions
In patients with concomitant diseases
Care should be taken in patients with advanced liver disease
Also in patients with debilitating disease
And in patients with impaired renal functions
Important
Never take Restyl without prescription
Physician’s assistance is a must when you want to discontinue the drug (cases of seizures have been reported)
Take care, not to end up as a drug abuser
Never escalate or reduce the dosage on your own
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Reshmi writes for Chillibreeze.
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